CGI PHARMACEUTICALS, INC.;GILEAD CONNECTICUT, INC.
发明人:
MITCHELL, SCOTT A.,DANCA, MIHAELA DIANA,BLOMGREN, PETER A.,DESIMONE, ROBERT W.,PIPPIN, DOUGLAS A. I.
申请号：
ES06718358
公开号：
ES2465469T3
申请日:
2006.01.13
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
At least one chemical entity selected from compounds of Formula 1 ** Formula ** and pharmaceutically acceptable salts, solvates, crystalline forms, and mixtures thereof, in which A is selected from O and S； B and D are selected from CH and N, provided that at least one of B and D is CH； R represents 0 to 2 substituents independently selected from hydroxy, nitro, cyano, optionally substituted amino, aminocarbonyl, halo, carboxy, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, sulfanyl, sulfinyl, sulfonyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted heterocycloalkyl； R1 is optionally substituted heteroaryl； W is optionally substituted heteroaryl； Z1 is -CR5R6-, wherein each R5 and R6 is independently selected from hydrogen, optionally substituted C1-C6 alkyl and halo； m is selected from 0, 1 and 2； Z2 is -CR7R8-, wherein each R7 and R8 is independently selected from hydrogen, optionally substituted C1-C6 alkyl and halo； n is selected from 0, 1 and 2； R2 is optionally substituted aryl； each of R3 and R4 is independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted aryl and optionally substituted heteroaryl, and in which "alkyl" refers to straight chain and branched chain having the indicated number of atoms carbon； "lower alkyl" refers to alkyl groups having one to four carbons； "alkenyl" refers to an unsaturated straight or branched chain alkyl group having at least one carbon-carbon double bond derived from the removal of a hydrogen atom from a single carbon atom from a precursor alkene.Al menos una entidad química seleccionada de entre compuestos de Fórmula 1**Fórmula** y sales farmacéuticamente aceptables, solvatos, formas cristalinas, y mezclas de los mismos, en la que A está seleccionado de entre O y S； B y D están seleccionados de entre CH y N, siempre que al menos uno de B y D sea CH； R
