AMINO ACID INHIBITORS OF CYTOCHROME P450

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专利权人:

SEQUOIA PHARMACEUTICALS; INC.

发明人:

EISSENSTAT, MICHAEL,DUAN, DEHUI,KANG, JIHYE

申请号：

EP09712109

公开号：

EP2280601A4

申请日:

2009.02.23

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Benzofuran-containing amino acid compounds are provided that are potent inhibitors of cytochrome P450 (CYP) enzymes. The compounds have the general structure where at least one of R1, R2, R3, R4, R5, and R6 is —S(O)n—(CH2)0-3-(benzofuranyl), —(CH2)1-5—N(R)(—SO2-benzofuranyl), —C(O)n—(CH2)0-3-(benzofuranyl), —(CH2)1-5—N(R)(C(═O)-(benzofuranyl), or C1-C6 alkylene-(benzofuranyl). Pharmaceutical compositions containing the inhibitors are provided and these compositions can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

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