CNRS Centre National de la Recherche Scientifique;Université de Rennes 1;Université d'Orléans
发明人:
申请号：
EP16306500.6
公开号：
EP3323428A1
申请日:
2016.11.17
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides nine c-FLIP inhibitors that are useful in the treatment of cancer, alone or in combination with other chemotherapeutic agents, in particular with TRAIL-based chemotherapeutic agents. The present invention also relates to pharmaceutical compositions and kits comprising at least one of the nine c-FLIP inhibitors and their use in methods for the treatment of cancer, in particular to overcome chemoresistance or to improve sensitivity of tumors to TRAIL-based therapy.
