INHIBITEURS SELECTIFS DE C-FLIP EN TANT QU'AGENTS ANTICANCEREUX

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专利权人:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -;UNIVERSITE DE RENNES 1;UNIVERSITE D'ORLEANS

发明人:

YAACOUB, KATHERINE,GUILLAUDEUX, THIERRY,DANIELLOU, RICHARD,LAFITE, PIERRE,ACI-SECHE, SAMIA,BONNET, PASCAL

申请号：

CA3043023

公开号：

CA3043023A1

申请日:

2017.11.17

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention provides nine selective c-FLIP inhibitors that are useful in the treatment of cancer, alone or in combination with other chemotherapeutic agents, in particular with TRAIL-based chemotherapeutic agents. The present invention also relates to pharmaceutical compositions and kits comprising at least one of the nine selective c-FLIP inhibitors and their use in methods for the treatment of cancer, in particular to overcome chemoresistance or to improve sensitivity of tumors to TRAIL-based therapy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/