CUEVAS, CARMEN,PEREZ, MARTA,FRANCESCH, ANDRES,FERNANDEZ, CAROLINA,CHICHARRO, JOSE LUIS,GALLEGO, PILAR,ZARZUELO, MARIA,MANZANARES, IGNACIO,MARTIN, MARIA JESUS,MUNT, SIMON
申请号：
HU0300648
公开号：
HU228789B1
申请日:
2001.05.15
申请国别(地区):
HU
年份:
2013
代理人:
摘要：
Preparation of an ecteinascidin product with a spiroamine-1,4-bridge involves forming a 1,4 bridge using a 1-labile, 10- hydroxy, 18-protected hydroxy, di-6,8-en-5-one fused ring compound. The C-18 protection is removed before spiroamine (preferably spiroquinoline) introduction. An independent claim is included for the manufacture of the ecteinascidin compound involving removing both protecting groups in a single step, according to the scheme. [Image] T : amino protecting group； and T' : hydroxy protecting group. ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.
