CUEVAS CARMEN,CARMEN CUEVAS,MANZANARES IGNACIO,IGNACIO MANZANARES,PEREZ MARTA,MARTA PEREZ,MARTIN MARIA JESUS,MARÍA JESÚS MARTÍN,RODRIGUEZ ALBERTO,ALBERTO RODRIGUEZ,MUNT SIMON,SIMON MUNT,MARTÍN MARÍA JESÚS
申请号：
PL358258
公开号：
PL215769B1
申请日:
2001.05.15
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
Preparation of an ecteinascidin product with a spiroamine-1,4-bridge involves forming a 1,4 bridge using a 1-labile, 10- hydroxy, 18-protected hydroxy, di-6,8-en-5-one fused ring compound. The C-18 protection is removed before spiroamine (preferably spiroquinoline) introduction. An independent claim is included for the manufacture of the ecteinascidin compound involving removing both protecting groups in a single step, according to the scheme. [Image] T : amino protecting group； and T' : hydroxy protecting group. ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.
