Dana-Farber Cancer Institute, Inc.;Massachusetts Institute Of Technology
发明人:
GOLDBERG, Michael Solomon,SCHMID, Daniela,IRVINE, Darrell J.,WUCHERPFENNIG, Kai
申请号：
EP16880151
公开号：
EP3393456A4
申请日:
2016.12.23
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent； and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset (e.g., an endogenous T-cell or a myeloid-derived suppressor cell). The present invention provides methods for forming and methods for using the particles. The particles described herein may be useful in treating and/or preventing proliferative disease, inflammatory disease, or neoplastic disorders (e.g., cancer, autoimmune diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a particle described herein.
