INC.;DANA-FARBER CANCER INSTITUTE;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
GOLDBERG, MICHAEL SOLOMON,SCHMID, DANIELA,IRVINE, DARRELL J.,WUCHERPFENNIG, KAI
申请号：
CA3009186
公开号：
CA3009186A1
申请日:
2016.12.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent； and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset (e.g., an endogenous T-cell or a myeloid-derived suppressor cell). The present invention provides methods for forming and methods for using the particles. The particles described herein may be useful in treating and/or preventing proliferative disease, inflammatory disease, or neoplastic disorders (e.g., cancer, autoimmune diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a particle described herein.
