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Use of substituted cyclohexanol ether derivatives e.g. as antimicrobial active substance, preferably antibacterial active substance and as anti-acne-, antidandruff-, deodorant- or antiperspirant active substance, and in cosmetic formulation
专利权人:
Merck Patent GmbH
发明人:
RUDOLPH, THOMAS,Thomas Rudolph,EISENBERG, SYLVIA,Sylvia Eisenberg
申请号:
DE102012016191
公开号:
DE102012016191A1
申请日:
2012.08.16
申请国别(地区):
DE
年份:
2014
代理人:
摘要:
Die vorliegende Erfindung betrifft die Verwendung mindestens eines Cyclohexanoletherderivats der Formel I als antimikrobieller Wirkstoff oder als Anti-Akne-, Antischuppen-, Deodorant- oder Antitranspirantwirkstoff, Zubereitungen enthaltend diese Verbindungen, sowie spezielle Cyclohexanoletherderivate.Use of substituted cyclohexanol ether derivatives (I) as an antimicrobial active substance, is claimed. Use of substituted cyclohexanol ether derivatives of formula (I) as an antimicrobial active substance, is claimed. R1-R5 : H, OH, OCOCH 3, O(CH 2CH 2O) nH, halo, 1-20C alkyl (optionally substituted by OH and optionally interrupted by -O-, -(C=O)-, -(CO)O- or cyclohexyl) or 1-20C O-alkyl; n : 1-20; and R6 : 1-20C alkyl (optionally substituted by OH) or -(CH 2CH 2O) nH. Independent claims are also included for: (1) a formulation comprising (I) and at least one carrier; (2) a composition comprising (I) and at least one antioxidant; (3) preparing the formulation, comprising mixing (I) with the carrier; and (4) 4-(2-hydroxy-ethoxy)-cyclohexanol, 2-(4-methoxy-cyclohexyloxy)-ethanol, 2-tert-butyl-4-methoxy-cyclohexanol, 2-methoxy-4-(3-methoxy-propyl)-cyclohexanol, 4-[3-(2-hydroxy-ethoxy)-propyl]-2-methoxy-cyclohexanol, hexanoic acid 3-(4-hydroxy-3-methoxy-cyclohexyl)-propyl ester, 4-(3-hydroxy-butyl)-2-methoxy-cyclohexanol, 4-(4-hydroxy-3-methoxy-cyclohexyl)-butan-2-one, 3-(4-hydroxy-cyclohexyl)-propionic acid 2-ethyl-hexyl ester, 1-cyclohexyl-3-(4-methoxy-cyclohexyl)-propane-1,3-diol derivatives of formula (IIa), 1-cyclohexyl-3-(4-methoxy-cyclohexyl)-propan-1-ol derivatives of formula (IIb), 3-cyclohexyl-1-(4-methoxy-cyclohexyl)-propan-1-ol derivatives of formula (IIc) and 1-(3-cyclohexyl-propyl)-4-methoxy-cyclohexane derivatives of formula (IId). [Image] [Image] [Image] ACTIVITY : Antibacterial; Antiseborrheic; Dermatological. The antibacterial activity of (I) was tested against Escherichia coli. The results showed that 2-cyclohexyloxy-ethanol (0.8% in water-(12%) etha
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