Use of substituted dicyclohexylmethanol derivatives as antimicrobial active substance and anti-acne-, antidandruff-, deodorant- or antiperspirant active substance, and in cosmetic- or pharmaceutical formulations and medical devices
RUDOLPH, THOMAS, DR.,Thomas, Dr. Rudolph,MUELLER, TATJANA,Tatjana Mueller
申请号：
DE102012016194
公开号：
DE102012016194A1
申请日:
2012.08.16
申请国别(地区):
DE
年份:
2014
代理人:
摘要：
Die vorliegende Erfindung betrifft die Verwendung mindestens eines Dicyclohexylmethanolderivats der Formel I als antimikrobieller Wirkstoff oder als Anti-Akne-, Antischuppen-, Deodorant- oder Antitranspirantwirkstoff, Zubereitungen enthaltend diese Verbindungen, sowie spezielle Diyclohexylmethanolderivate und ein Verfahren zu deren Herstellung.Use of substituted dicyclohexylmethanol derivatives (I) as an antimicrobial active substance and an anti-acne-, antidandruff-, deodorant- or antiperspirant active substance, is claimed. Use of substituted dicyclohexylmethanol derivatives of formula (I) as an antimicrobial active substance and an anti-acne-, antidandruff-, deodorant- or antiperspirant active substance, is claimed. R1-R10 : H, OH, OCOCH 3, CH 2OH, SO 3H, halo, 1-20C alkyl or 1-20C alkoxy. Provided that at least one of the groups R1-R10 is OH or alkoxy group having 1-20 carbon atoms. Independent claims are also included for: (1) a formulation comprising (I) and at least one carrier； (2) preparing the formulation, comprising mixing (I) with the carrier； (3) (I)； and (4) preparing (I). ACTIVITY : Antimicrobial； Antiseborrheic； Dermatological. The antibacterial activity of (I) was tested against Staphylococcus epidermidis (strain ATCC 12228). The results showed that 4-(cyclohexyl-hydroxy-methyl)-cyclohexanol (2% in water-(12%) ethanol mixture) decreased colony forming units from 1.6x 10 4>； to 7.4x 10 3>；. MECHANISM OF ACTION : None given.
