THE GENERAL HOSPITAL CORPORATION;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
BEAN, BRUCE P.,WOOLF, CLIFFORD J.
申请号：
DK07862114
公开号：
DK2101819T3
申请日:
2007.11.19
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors； and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
