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Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
- 专利权人:
- Deciphera Pharmaceuticals; LLC
- 发明人:
- FLYNN, Daniel L.,KAUFMAN, Michael D.,PETILLO, Peter A.
- 申请号：
- ES12878321
- 公开号：
- ES2663605T3
- 申请日:
- 2012.06.07
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- A compound selected from the group consisting of 1- (4-chloro-3- (1-methyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) phenyl) -3- (3-cyanophenyl) urea, 1- (3-cyanophenyl) -3- (5- (1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridine) 3-yl) -2-fluorophenyl) urea, 1- (benzo [b] thiophen-3-yl) -3- (2-fluoro-4methyl-5- (1-methyl-7- (methylamino) -2-oxo -1,2-dihydro-1,6-naphthyridin-3-yl) phenyl) urea, 1- (benzo [b] thiophene-3-yl) -3- (2,4-difluoro-5- (1-methyl -7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) phenyl) urea, 1- (5- (1-ethyl-7- (methylamino) -2-oxo -1,2-dihydro-1,6-naphthyridin-3-yl) -2,4-difluorophenyl) -3- (3-fluorophenyl) urea, 1- (5- (1-ethyl-7- (methylamino)) - 2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -2,4-difluorophenyl) -3-phenylurea, 1- (3-chlorophenyl) -3- (5- (1-ethyl- 7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -2,4-difluorophenyl) urea, 1- (3-cyanophenyl) -3- (5- (1 -ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -2,4-difluorophenyl) urea, 1- (benzo [b] thiophene-3-yl ) -3- (5- (1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthiri din-3-yl) -2,4-difluorophenyl) urea, 1- (5- (7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) - 4-Chloro-2-fluorophenyl) -3- (3-fluorophenyl) urea, 1- (5- (7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridine-3- il) -4-chloro-2-fluorophenyl) -3-phenylurea, 1- (4-chloro-2-fluoro-5- (1-isopropyl-7- (methylamino) -2-oxo-1,2-dihydro- 1,6-naphthyridin-3-yl) phenyl) -3-phenylurea, 1- (5- (1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3 -yl) -2-fluoro-4-methylphenyl) -3-phenylurea, 1- [4-chloro-5- (1-ethyl-7-methylamino-2-oxo-1,2-dihydro- [1,6] naphthyridin-3-yl) -2-fluoro-phenyl] -3- (3-fluoro-phenyl) -urea, 1- [4-chloro-5- (1-ethyl-7-methylamino-2-oxo-1, 2-dihydro- [1,6] naphthyridin-3-yl) -2-fluoro-phenyl] -3- (2-fluoro-phenyl) -urea, 1- (4-chloro-3- (1-ethyl-7 - (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -2-fluoro
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
