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PI3K Cough Inhibitors
专利权人:
ГлаксоСмитКлайн Интеллекчуал Проперти (N 2) Лимитед (GB)
发明人:
МЕРЛО ПИЧ Эмилио (GB)
申请号:
RU2014128386
公开号:
RU2014128386A
申请日:
2013.02.04
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The compound of formula (I) where X is —CH— and Υ is 4-pyridazinyl; or X is -Ν-, and Υ is 4-morpholinyl; or a pharmaceutically acceptable salt thereof for use in the treatment of cough. 2. A compound representing 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3-pyridinyl} benzenesulfonamide: or a pharmaceutically acceptable salt thereof for use in the treatment of cough. 3. The compound of claim 2, which is 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3-pyridinyl} benzene sulfonamide as the free base. four. The compound according to any one of paragraphs. 1-3, where the cough is an idiopathic chronic cough, a cough variant of asthma, a cough associated with a chest tumor or lung cancer, a viral or post-viral cough, cough upper respiratory tract syndrome (UACS), or post-nasal congestion syndrome or cough associated with gastroesophageal reflux disease (both with acid reflux and non-acid content reflux), chronic bronchitis, chronic obstructive pulmonary disease (COPD), interstitial lung disease, stasis oh heart failure, sarcoidosis or infektsiey.5. The use of a compound representing 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3-pyridinyl} benzene sulfonamide: or a pharmaceutically acceptable salt thereof in the manufacture medicines for use in the treatment of cough. 6. A method for treating cough, comprising administering to a patient in need thereof a safe and effective amount of a compound 2,4-difluoro-N- {2- (methyloxy) -5- [4- (4-pyridazinyl) -6-quinolinyl] -3- pyridinyl} -benzenesulfonamide: or a pharmaceutically acceptable salt thereof.1. Соединение формулы (I)где X представляет собой -CH-, и Υ представляет собой 4-пиридазинил; илиX представляет собой -Ν-, и Υ представляет собой 4-морфолинил;или его фармацевтически приемлемая соль для применения в лечении кашля.2. Соединение, представляющее собой 2,4-дифтор-N-{2-(метилокси)-5-[4-(4-пиридазинил)-6-хинолинил]-3-пиридинил}бензолсуль
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