Balkrishen Bhat,Eric E. Swayze,Thazha P. Prakash,Charles Allerson,Prasad Dande,Richard H. Griffey
申请号：
US11569939
公开号：
US08394947B2
申请日:
2004.03.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment the oligomeric compounds comprise double stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.
