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Data from: CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer's disease
- 负责人：
- DOI：
- doi:10.5061/dryad.5f82b32
- 摘要：
- were increased during the preclinical, prodromal and dementia stages of AD. High levels of these biomarkers were associated with increased CSF levels
Data from: Prophylactic digoxin treatment reduces IL-17 production in vivo in the neonatal calf and moderates RSV-associated disease
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.72db024
- 摘要：
- ves is pathologically and immunologically similar to RSV infection in infants, and is therefore a useful preclinical model for testing novel therapeutics. Treatment
Data from: TSPO PET Using [18F]PBR111 reveals persistent neuroinflammation following acute diisopropylfluorophosphate intoxication in the rat
- 负责人：
- Lein, Pamela J.
- 关键词：
- Diisopropylfluorophosphate GFAP IBA1 positron emission tomography organophosphate neuroinflammation TSPO
- DOI：
- doi:10.5061/dryad.7c7b561
- 摘要：
- measures of neuroinflammation in a preclinical model of acute intoxication with the OP diisopropylfluorophosphate (DFP). Adult male Sprague Dawley rats
Data from: Antibodies to Plasmodium vivax Reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations
- 负责人：
- DOI：
- doi:10.5061/dryad.p678q83
- 摘要：
- =0.45-0.50, P?0.032). Conclusion/Significance. Our results indicate that PvRBP2b warrants further preclinical development as a blood-stage
Data from: Low fasting serum insulin and dementia in nondiabetic women followed for 34 years
- 负责人：
- DOI：
- doi:10.5061/dryad.21v1r72
- 摘要：
- t was not attributable to preclinical dementia or impaired insulin secretion. This condition suggests a new pathway to dementia, which differs from the metabolic
Data from: Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks
- 负责人：
- 关键词：
- live-cell microscopy;end resection;Schizosaccharomyces pombe;DNA repair;DNA double-strand break
- DOI：
- doi:10.5061/dryad.1db5500
- 摘要：
- ). In preclinical models, PARPi resistance is tied to altered nucleolytic processing (resection) at the 5' ends of a DSB. For example, loss of 53BP1 or Rev7/MAD2L2/FANCV
Data from: Looking up: a dozen years of evolution of neurology clerkships in the United States
- 负责人：
- DOI：
- doi:10.5061/dryad.gh49142
- 摘要：
- 9% in 2005 to 23% in 2017. Twenty-seven percent also serve as division chief/director, and 22% direct a preclinical neuroscience course. Forty-nine percent
Therapeutic potential of rhesus theta (θ) defensin-1 in cystic fibrosis airway infection and inflammation
- 负责人：
- 关键词：
- Clinical and Experimental Therapeutics cystic fibrosis infection inflammation preclinical drug development
- DOI：
- doi:10.25549/usctheses-c40-309144
- 摘要：
- decline in patients receiving chronic prednisone or high-dose ibuprofen (Eigen et al., 1995; Konstan et al., 1995). However, serious adverse effects li
Data from: MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates
- 负责人：
- Sacha, Jonah B.
- DOI：
- doi:10.5061/dryad.vm36c
- 摘要：
- and Mycobacterium tuberculosis infection. These results demonstrate that NHP and human MR1 and MAITs function analogously, and establish a preclinical animal model to test MAIT
Data from: Cognition at age 70: life course predictors and associations with brain pathologies
- 负责人：
- DOI：
- doi:10.5061/dryad.nt561v7
- 摘要：
- Objective: To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC
