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Data from: Specific alleles at immune genes, rather than genome-wide heterozygosity, are related to immunity and survival in the critically endangered Attwater's prairie-chicken
- 负责人：
- DOI：
- doi:10.5061/dryad.dm437
- 摘要：
- was related to alleles of the innate (Toll-like receptors, TLRs) and adaptive (major histocompatibility complex, MHC) immune systems, but not to genome-wide
Data from: Costs of immunity and their role in the range expansion of the house sparrow in Kenya
- 负责人：
- DOI：
- doi:10.5061/dryad.fn0f4
- 摘要：
- of Toll-like receptors (TLRs), leukocyte receptors that instigate inflammatory responses when bound to microbial elements, was related to the range expansion across the country
Data from: Genetic depletion at adaptive but not neutral loci in an endangered bird species
- 负责人：
- DOI：
- doi:10.5061/dryad.8c9s1
- 摘要：
- microsatellite loci and adaptive SNP variation in five Toll-like receptor (TLR) immune system genes. Bottleneck tests confirm genetic drift as the main force shaping
Data from: NF-?B pathways are involved in M1 polarization of RAW 264.7 macrophage by polyporus polysaccharide in the tumor microenvironment
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.6fh45
- 摘要：
- by interfering with Toll-like receptor (TLR)-4, INOS and cyclooxygenase (COX)-2. Our results indicate that PPS activates macrophages through TLR4/NF
Data from: The role of platelets in mediating a response to human influenza infection
- 负责人：
- DOI：
- doi:10.5061/dryad.786b9q0
- 摘要：
- to C3 release from platelets as a function of TLR7 and C3 leads to neutrophil-DNA release and aggregation. TLR7 specificity is confirmed in murine models
Data from: Impaired T Cell Responsiveness to Interleukin-6 in Hematological Patients with Invasive Aspergillosis
- 负责人：
- DOI：
- doi:10.5061/dryad.n9b7r
- 摘要：
- of the pattern recognition receptors pentraxin 3, dectin-1, and Toll-like receptors (TLR) 2 and 4 in peripheral blood of chemotherapy and HSCT recipients with IMI. Compared
Data from: TLR and IMD signaling pathways from Caligus rogercresseyi (Crustacea: Copepoda): in silico gene expression and SNPs discovery
- 负责人：
- DOI：
- doi:10.5061/dryad.sm32j
- 摘要：
- The Toll and IMD signaling pathways represent one of the first lines of innate immune defense in invertebrates like Drosophila. However, for crustaceans like Caligus rogercresseyi, there is very little genomic information and, consequently, understanding of immune mechanisms. Massive sequencing data obtained for three developmental stages of C. rogercresseyi were used to evaluate in silico the expression patterns and presence of SNPs variants in genes involved in the Toll and IMD pathways. Through RNA-seq analysis, which used 20 contigs corresponding to relevant genes of the Toll and IMD pathways, an overexpression of genes linked to the Toll pathway, such as toll3 and Dorsal, were observed in the copepod stage. For the chalimus and adult stages, overexpression of genes in both pathways, such as Akirin and Tollip and IAP and Toll9, respectively, were observed. On the other hand, PCA statistical analysis inferred that in the chalimus and adult stages, the immune response mechanism was more developed, as evidenced by a relation between these two stages and the genes of both pathways. Moreover, 136 SNPs were identified for 20 contigs in genes of the Toll and IMD pathways. This study provides transcriptomic information about the immune response mechanisms of Caligus, thus providing a foundation for the development of new control strategies through blocking the innate immune response.
Data from: Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.6hf1pc1
- 摘要：
- with specific inhibitors, analysis of the products in a Toll-like receptor reporter cell line assay, and insulin removal from the products by immunopurification
Data from: Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease
- 负责人：
- DOI：
- doi:10.5061/dryad.s1bg6
- 摘要：
- t on the expression of certain pro-inflammatory mediators, such as IL-8 (CXCL8) and TLR2, but had a stimulatory effect on specific molecules such as the Interleukin 10
Therapeutic potential of rhesus theta (θ) defensin-1 in cystic fibrosis airway infection and inflammation
- 负责人：
- 关键词：
- Clinical and Experimental Therapeutics cystic fibrosis infection inflammation preclinical drug development
- DOI：
- doi:10.25549/usctheses-c40-309144
- 摘要：
- diffusible material we found TLR and adapter protein mRNA downregulation associated with reduced inflammatory cytokine release. Collectively, this body
