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Data from: Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated ROS production
- 负责人：
- 关键词：
- Mitochondria;reactive oxygen species;Placenta;fetal loss;Oxidative stress;Polycystic ovary syndrome
- DOI：
- doi:10.5061/dryad.30bf364
- 摘要：
- in DHT+insulin?treated pregnant rats, an effect related to changes in Keap1/Nrf2 and NF?B signaling. However, NAC administration resulted in fetal
Data from: A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life history adaptation
- 负责人：
- DOI：
- doi:10.5061/dryad.057r9
- 摘要：
- in allele frequency concurrent with seasonal change. We tested the alleles for effects on levels of insulin signaling, fecundity, development time, body si
Data from: Ablation of insulin-producing cells prevents obesity but not premature mortality caused by a high-sugar diet in Drosophila
- 负责人：
- DOI：
- doi:10.5061/dryad.t04v4
- 摘要：
- concentrations of sucrose as the carbohydrate source, and yeast as the protein source. Dampening the signal through the insulin/IGF signalling (IIS) pathway
Data from: Monarch butterflies use an environmentally sensitive, internal timer to control overwintering dynamics
- 负责人：
- DOI：
- doi:10.5061/dryad.fd517kq
- 摘要：
- e implicated to be the proximate timing mechanism. Ecdysteroid, JH, and insulin/insulin-like peptide (IIS) signaling are major targets of the diapause program
Data from: Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears
- 负责人：
- DOI：
- doi:10.5061/dryad.sc38b
- 摘要：
- ter understand these seasonal transitions, we performed insulin and glucose tolerance tests in captive grizzly bears, characterized the annual profiles
Data from: Insulin-insensitivity of male genitals maintains reproductive success in Drosophila
- 负责人：
- DOI：
- doi:10.5061/dryad.44bm68r
- 摘要：
- of the male genitalia is a consequence of low insulin sensitivity through a tissue-specific reduction in expression of FOXO, a negative growth regulator. Des
Data from: The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals
- 负责人：
- DOI：
- doi:10.5061/dryad.pj0p3
- 摘要：
- -2. The MML-1:MXL-2 and MDL-1:MXL-1 complexes function in both the insulin signaling and dietary restriction pathways. Furthermore, decreased insulin-like/IGF-1
Data from: Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
- 负责人：
- DOI：
- doi:10.5061/dryad.75940
- 摘要：
- indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone
Data from: Longevity is determined by ETS transcription factors in multiple tissues and diverse species
- 负责人：
- DOI：
- doi:10.5061/dryad.5qv9750
- 摘要：
- outcomes, which reveals a multi-tissue and multi-species role for an entire protein family: the E-twenty-six (ETS) TFs. In Drosophila, reduced insulin/IGF
Proinsulin-transferrin fusion protein as a liver targeting insulin therapeutic in Type 1 diabetes treatment
- 负责人：
- 关键词：
- Pharmaceutical Sciences proinsulin-transferrin fusion protein liver targeting diabetes long-acting insulin therapeutic
- DOI：
- doi:10.25549/usctheses-c40-250950
- 摘要：
- ver was investigated from two aspects: (1) activation status of hepatic IR signaling network; and (2) intervention of glucose metabolism in liver. Desired therapeutic
