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Data from: Insulin signaling’s role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.35g4j2q
- 摘要：
- remain poorly understood. We assessed the functions of members of the insulin/insulin-like signaling pathway (IIS) in the regulation of nutriti
Data from: Stage-specific plasticity in ovary size is regulated by insulin/insulin-like growth factor and ecdysone signalling in Drosophila
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- 关键词：
- critical period for environmental sensitivity ecdysone signaling insulin/insulin-like growth factor signaling larval nutrition ovary size
- DOI：
- doi:10.5061/dryad.688nk
- 摘要：
- /insulin-like growth factor and the ecdysone-signaling pathways, modulate the timing and rates of all three developmental processes. The change in sensitivity in the ovary res
Data from: Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
- 负责人：
- DOI：
- doi:10.5061/dryad.6b604g8
- 摘要：
- behavior by acutely recruiting two pore-restricting proteins, amisyn and dynamin-1, to the exocytosis site in insulin-secreting beta-cells. cAMP elevati
Data from: Insulin-insensitivity of male genitals maintains reproductive success in Drosophila
- 负责人：
- DOI：
- doi:10.5061/dryad.44bm68r
- 摘要：
- city of the male genitalia is a consequence of low insulin sensitivity through a tissue-specific reduction in expression of FOXO, a negative growth regulator. Des
Proinsulin-transferrin fusion protein as a liver targeting insulin therapeutic in Type 1 diabetes treatment
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- 关键词：
- Pharmaceutical Sciences proinsulin-transferrin fusion protein liver targeting diabetes long-acting insulin therapeutic
- DOI：
- doi:10.25549/usctheses-c40-250950
- 摘要：
- Long-acting insulin (INS) analogs have been used in the treatment of INS-deficient diabetes patients to meet INS needs between meal times and duri
Data from: Longevity is determined by ETS transcription factors in multiple tissues and diverse species
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- DOI：
- doi:10.5061/dryad.5qv9750
- 摘要：
- , confirming their conserved function in ageing and revealing that the roles of ETS TFs in physiology and lifespan are conserved throughout the family, bot
Data from: Higher insulin resistance & adiposity in post-menopausal women with breast cancer treated with aromatase inhibitors
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- 关键词：
- DOI：
- doi:10.5061/dryad.2n054k4
- 摘要：
- induce obesity and insulin resistance when used in treatment of breast cancer. Design: Case-control study Setting: University teac
Data from: Experimentally reduced insulin/IGF-1 signalling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
- 负责人：
- DOI：
- doi:10.5061/dryad.8d2t65n
- 摘要：
- ng genes leading to excessive biosynthesis in late-life. The hyper-function theory uniquely predicts that optimizing nutrient-sensing molecular signallin
Data from: The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals
- 负责人：
- DOI：
- doi:10.5061/dryad.pj0p3
- 摘要：
- -2. The MML-1:MXL-2 and MDL-1:MXL-1 complexes function in both the insulin signaling and dietary restriction pathways. Furthermore, decreased insulin-like/IGF-1
Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
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- 关键词：
- DOI：
- doi:10.5061/dryad.r34k1
- 摘要：
- known for suppression of antigen presentation by dendritic and B cells. MARCH1 was recently found to negatively regulate the cell surface levels of the insulin
