Data from: Predicting drug-induced liver injury using ensemble learning methods and molecular fingerprints

负责人：

关键词：

DOI：

doi:10.5061/dryad.1k8m6p2

摘要：

t the hepatotoxicity of compounds during the early stages of drug trials. In this study, we developed an ensemble model using three machine learning algorithms and 12

Data from: Bioprinted liver provides early insight into the role of Kupffer cells in TGF-?1 and methotrexate-induced fibrogenesis

负责人：

关键词：

DOI：

doi:10.5061/dryad.5rc1973

摘要：

Hepatic fibrosis develops from a series of complex interactions among resident and recruited cells making it a challenge to replicate using standard

Data from: Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost

负责人：

Salin, Karine

关键词：

Liver atrophy High resolution respirometry In vivo MitoB probe Mitochondrial respiratory state

DOI：

doi:10.5061/dryad.v0vg627

摘要：

ATP without a concomitant increase in energy dissipated through proton leakage. However, the reduction in total hepatic metabolic capacity in fasted

Data from: Levels of 8-oxodG predict hepatobiliary-pathology in Opisthorchis viverrini endemic settings in Thailand

负责人：

关键词：

advanced hepatobiliary pathologies;Biomarkers;fibrosis;Thailand;urine 8-oxodG;cholangiocarcinoma;chronic inflammation;receiver operating characteristic curve analyses

DOI：

doi:10.5061/dryad.pd6mn

摘要：

Opisthorchis viverrini is distinct among helminth infections as it drives a chronic inflammatory response in the intrahepatic bile duct tha

Data from: Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide

负责人：

关键词：

DILI;Flutamide;2-hydroxyflutamide;Mitochondria

DOI：

doi:10.5061/dryad.jj456

摘要：

The androgen receptor antagonist, flutamide, is strongly associated with idiosyncratic drug-induced liver injury (DILI). Following administrati

Data from: Identification of candidate risk factor genes for human idelalisib toxicity using a collaborative cross approach

负责人：

关键词：

DOI：

doi:10.5061/dryad.qn8p2n0

摘要：

ng chronic lymphocytic leukemia and follicular lymphoma. In clinical trials, however, idelalisib was associated with rare, but potentially serious liver and lung toxiciti

Data from: Genetic mapping of novel loci affecting canine blood phenotypes

负责人：

关键词：

genome-wide association study canine genetics clinical pathology

DOI：

doi:10.5061/dryad.30c8p

摘要：

activity a less useful marker of hepatic injury in these individuals. Overall, these associations provide a roadmap for identifying causal variants tha