Data from: Nonspecific PCR amplification by high-fidelity polymerases: implications for next-generation sequencing of AFLP markers.

负责人：

Brelsford, Alan

关键词：

Population genomics AFLP 454 PCR proofreading polymerase high-fidelity polymerase

DOI：

doi:10.5061/dryad.1hg75

摘要：

High-fidelity “proofreading” polymerases are often used in library construction for next-generation sequencing projects, in an effort to minimize

Data from: Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ?

负责人：

关键词：

molecular dynamics;DNA Polymerase;Mutation;Cancer

DOI：

doi:10.5061/dryad.1sb340g

摘要：

proposed to increase genome instability by disrupting exonucleolytic proofreading, the P286R variant was later found to be significantly more pathogenic tha