Data from: A systems toxicology approach for the prediction of kidney toxicity and its mechanisms in vitro

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关键词：

Kidney toxicity;In Vitro and Alternatives;Prediction;mechanisms;Systems Toxicology

DOI：

doi:10.5061/dryad.646v2r1

摘要：

The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue

Cylindrospermopsin toxicity in mice following a 90-d oral exposure

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关键词：

Biochemistry Cell Biology Genetics Pharmacology 59999 Environmental Sciences not elsewhere classified 39999 Chemical Sciences not elsewhere classified Marine Biology 60506 Virology

DOI：

doi:10.6084/m9.figshare.6182216.v1

摘要：

suggestive of toxicity. At the end of exposure, toxicity was noted at all dose levels, and the 75 μg/kg group exhibited significant effects in liver and kidney

Data from: Adjunctive clindamycin for cellulitis: clinical trial comparing flucloxacillin with or without clindamycin for the treatment of limb cellulitis

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关键词：

limb;erysipelas;flucloxacillin;clindamycin;diarrhoea;cellulitis

DOI：

doi:10.5061/dryad.5q1j0

摘要：

, randomised controlled trial. Setting: Emergency department attendances and general practice referrals within 20 hospitals in England. Interventions: Flucloxaci

Data from: A rat liver transcriptomic point of departure predicts a prospective liver or non-liver apical point of departure

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关键词：

transcriptome;Benchmark Dose;Point of Departure;Apical Effect;Risk assessment

DOI：

doi:10.5061/dryad.pvmcvdngd

摘要：

molecules obtained from Open TG-GATES (Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System) (632 datasets), the hypothesis was tested tha

Antimalarial activity, toxicity, pharmacokinetics and metabolic drug interaction of Plumbago Indica linn.

负责人：

Kesara Na-Bangchang, Advisor

关键词：

Plumbagin Antimalarial Plasmodium falciparum Plasmodium berghei Permeability Transport Efflux transporters Caco-2 cell P-glycoprotein Pharmacokinetics

DOI：

doi:10.14457/tu.the.2015.159

摘要：

up to 100 (single oral dose) and 25 (daily doses for 28 days) mg/kg body weight for acute and subacute toxicity, respectively whereas toxicity test

Data from: Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children

负责人：

关键词：

influenza;cochrane;neuraminidase inhibitor;clinical study reports;relenza;zanamivir;oseltamivir

DOI：

doi:10.5061/dryad.77471

摘要：

, psychiatric effects and renal events in adults and vomiting in children. The lower bioavailability may explain the lower toxicity of zanamivir compared