HUBY, NICHOLAS JOHN SILVESTER,LOPEZ-TAPIA, FRANCISCO JAVIER,SO, SUNG-SAU
申请号：
CA2893637
公开号：
CA2893637A1
申请日:
2013.12.09
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
