DEWDNEY, NOLAN JAMES,LOU, YAN,SJOGREN, ERIC BRIAN,SOTH, MICHAEL,SWEENEY, ZACHARY KEVIN
申请号：
CA2728683
公开号：
CA2728683C
申请日:
2009.06.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides 5 -phenyl- 1H-pyrazin-2-one derivativesaccording to generic Formulae I-V:wherein, variables Q, R, Y1, Y2, Y2', Y3, Y4, n and m are defined as describedherein, which inhibit Btk. The compounds disclosedherein are useful to modulate the activity of Btk and treat diseasesassociated with excessive Btk activity. The compounds are furtheruseful to treat inflammatory and auto immune diseases associated with aberrantB-cell proliferation such as rheumatoid arthritis.Also disclosed are compositions comprising compounds of Formulae I-V and atleast one carrier, diluent or excipient.
