use of a quinoline-derived compound, its combination, pharmaceutical composition, use of said combination, product, process for preparing a compound and said compound
ANIL KOUL,DAVID FRANCIS ALAIN LANÇOIS,ELISABETH THÉRÈSE JEANNE PASQUIER,JÉRÔME EMILE GEORGES GUILLEMONT,KOENRAAD JOZEF LODEWIJK MARCEL ANDRIES,LEO JACOBUS JOZEF BACKX,LIEVEN MEERPOEL
申请号：
BRPI0614493
公开号：
BRPI0614493B1
申请日:
2006.07.31
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
use of a quinoline-derived compound, its combination, pharmaceutical composition, use of said combination, product, process for preparing a compound and said compound. The use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is different from a mycobacterial infection, said compound being a compound of formula (1), a pharmaceutically acceptable acid or base addition salt. acceptable, a quaternary amine, a stereochemically isomeric form, a tautomeric form or a n-oxide form thereof, wherein R 14 is hydrogen, halo, haloalkyl, cyano, hydroxy, air, het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, aralkyl or di (ar) alkyl； p is 1 to 3； s is a at 4； R2 is hydrogen； halo； alkyl； hydroxy； mercapto； optionally substituted alkyloxy； alkyloxyalkyloxy； alkylthio； mono or di (alkyl) amino wherein alkyl may be optionally substituted； air； het or a radical of formula； R3 is alkyl, air, aralkyl, het or hetalkyl； q is a 4； R 4 and R 4 independently are hydrogen, alkyl or benzyl； or and may be taken together including the n to which they are attached； R6 is hydrogen, halo, haloalkyl, hydroxy, air, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, aralkyl or di (ar) alkyl； or two vicinal radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl； r is 1 to 5； R7 is hydrogen, alkyl, ar or het； R 8 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono- or di (alkyl) amino carbonyl, air, het, alkyl substituted by one or two het, alkyl substituted by one or two air, het-c (= o ) - or ar-c (= o) -； provided that when the radical containing R 3 is placed at the 3 position of the quinoline moiety； R2 is placed in position 4 and R2 is placed in position 2 and represents hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di (alkyl) amino or a radical of formula (iii), so s it's 1 to 4.uso de um composto derivado de quinoli
