Compounds derived from fluormetil - 5.6 - dihydro - 4H - [1,3] - 2 - ilamina oxazin as BACE1 inhibitors； extraction process； Pharmaceutical composition containing them, and their use for Therapeutic and / or prophylactic Treatment of Alzheimer's disease, Amyotrophic lateral sclerosis, cancer, Cardiovascular Diseases and Gastrointestinal Diseases, among others.

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专利权人:

F. HOFFMANN-LA ROCHE AG;SIENA BIOTECH S.P.A.

发明人:

HILPERT HANS,WOLTERING, THOMAS,HUMM, RONALD

申请号：

CL2014001838

公开号：

CL2014001838A1

申请日:

2014.07.11

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

Provided herein is a compound of formula I: as wells as a pharmaceutical composition, a process of making and a method of using a compound of formula I. The compounds of formula I are BACE1 inhibitors useful for the treatement of, for example, Alzheimer's Disease.COMPUESTOS DERIVADOS DE FLUOROMETIL-5,6-DIHIDRO-4H-[1,3]OXACINAS-2-ILAMINAS CON ACTIVIDAD INHIBIDORA DE BACE1； PROCESO DE PREPARACIÓN； COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE； USO EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ESCLEROSIS LATERAL AMIOTRÓFICA, CÁNCER, ENFERMEDADES CARDIOVASCULARES, ENTRE OTRAS.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/