Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases

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专利权人:

Institute of Organic Chemistry and Biochemistry AS CR v.v.i.;The Johns Hopkins University

发明人:

Slusher, Barbara,Rojas, Camilo,Thomas, Ajit G.,Nencka, Radim,Šála, Michal,Hrebabecký, Hubert

申请号：

AU2018205277

公开号：

AU2018205277A1

申请日:

2018.01.05

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided.

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中国工程科技知识中心

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