The present invention provides a spray-dried powder comprising vancomycinhydrochloride, and an industrialmanufacturing method thereof. The industrial manufacturing method comprises:using a vancomycin hydrochloride solution with thepurity of not lower than 95%, adding a stabilizing agent and a solubilizingagent in the solution to increase the stability and theconcentration of the solution, concentrating the vancomycin hydrochloridecomposite solution to 20%-30wt.%, and performing spraydrying in this concentration to obtain a vancomycin hydrochloride spray-driedpowder with the impurity B of lower than 1.5%.
