The present invention provides a spray-dried powder comprising vancomycin hydrochloride, and an industrial manufacturing method thereof. The industrial manufacturing method comprises: using a vancomycin hydrochloride solution with the purity of not lower than 95%, adding a stabilizing agent and a solubilizing agent in the solution to increase the stability and the concentration of the solution, concentrating the vancomycin hydrochloride composite solution to 20%-30wt.%, and performing spray drying in this concentration to obtain a vancomycin hydrochloride spray-dried powder with the impurity B of lower than 1.5%.
