Provided are an ultrasound diagnosis apparatus and method for analyzing a contrast enhanced ultrasound image. The ultrasound diagnosis apparatus and method determine, by analysis, causes of defects in a frame of an ultrasound image based on a time intensity curve and allow visual display of the defective frame based on the determined causes. Furthermore, the ultrasound diagnosis method and apparatus may provide a user interface for quick access to causes of defects in a frame of the ultrasound image and to a position of the defective frame.