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Lateral flow immunoassay for complement activation and methods of use for point-of-care assessment of complement-associated disorders
专利权人:
Don W. Moss;Paul Olson
发明人:
Paul Olson,Don W. Moss
申请号:
US13287432
公开号:
US09182396B2
申请日:
2011.11.02
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method for treating an individual at risk for a complement-associated disorder is provided, including: (a) obtaining a sample of a body fluid from the individual; (b) measuring a complement activation level in the sample via a point-of-care lateral flow immunoassay; (c) correlating the complement activation level in the sample to a risk of a complement-associated disorder by comparing the complement activation level in the sample to a reference level in a control, wherein a deviation in complement activation level in the sample compared to the reference level in the control indicates the individual is at risk for a complement-associated disorder; (d) selecting a treatment for the individual, based on the correlating of step (c); and (e) treating the individual with the treatment selected in accordance with step (d). Lateral flow immunoassays and a method of monitoring an individual suffering from a complement-associated disorder are also provided herein.
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