BONI, LAWRENCE T.,MILLER, BRIAN S.,MALININ, VLADIMIR,LI, XINGONG
申请号：
CA2614764
公开号：
CA2614764C
申请日:
2006.07.19
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Provided are lipid antiinfective formulations substantially free of anioniclipids with a lipid to antiinfective ratio is about 1 :1 to about 4:1, and amean average diameter of less than about 1 µm. Also provided is a method ofpreparing a lipid antiinfective formulation comprising an infusion process.Also provided are lipid antiinfective formulations wherein the lipid to drugratio is about 1 : 1 or less, about 0.75:1 or less, or about 0.50:1 or lessprepared by an in line fusion process. The present invention also relates to amethod of treating a patient with a pulmonary infection comprisingadministering to the patient a therapeutically effective amount of a lipidantiinfective formulation of the present invention. The present invention alsorelates to a method of treating a patient for cystic fibrosis comprisingadministering to the patient a therapeutically effective amount of a lipidantiinfective formulation of the present invention.
