University of Florida Research Foundation; Incorporated
发明人:
Robert William Huigens, III,Yasmeen Abouelhassan,Akash Basak
申请号：
US16467461
公开号：
US20190373890A1
申请日:
2017.12.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides novel compounds of Formula (I′；) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and/or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and/or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and/or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).
