ONO TSUBASA,小野 翼,YAMAGUCHI TSUBASA,山口 翼,ISHIDA KAZUHIRO,石田 和裕
申请号：
JP2016174044
公开号：
JP2018039749A
申请日:
2016.09.06
申请国别(地区):
JP
年份:
2018
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide semisolid preparations for oral administration in which the taste of a formulation is improved and in which decreased content and decreased thermal stability in an acidic drug preparation are suppressed, and to provide production methods thereof.SOLUTION: A semisolid preparation for oral administration contains (A) gelatin, (B) water, and (C) at least one drug selected from the group consisting of aspirin, ibuprofen, acetaminophen, loxoprofen, and salts thereof, having a pH of 1.0 to 3.5. A production method of a semisolid preparation for oral administration comprises gelating a liquid raw material in which the component (A) and (C) are dispersed into the component (B) and whose pH is 1.0 to 3.5.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】製剤の味を改善し、酸性薬物の製剤中での含有量低下ならびに熱安定性の低下を抑制した内服用半固形製剤及びその製造方法。【解決手段】ゼラチン(A)と、水(B)と、アスピリン、イブプロフェン、アセトアミノフェン、ロキソプロフェン及びその塩からなる群から選択される少なくとも1種の薬物(C)とを含有し、pHが1.0~3.5である内服用半固形製剤。前記(B)成分中に前記(A)成分及び前記(C)成分が分散され、pHが1.0~3.5である原料液をゲル化させる工程を有する、内服用半固形製剤の製造方法。【選択図】なし
