PETITES MOLECULES MODIFIEES D'ARN D'INTERFERENCE ET LEURS PROCEDES D'UTILISATION

• 收藏
• 分享

专利权人:

CHIRON CORPORATION

发明人:

HAN, JANG,SEO, MI YOUNG,HOUGHTON, MICHAEL

申请号：

CA2493949

公开号：

CA2493949C

申请日:

2003.07.25

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention provides double-stranded RNA molecules that mediate RNAinterference in target cells, preferably hepatic cells. The invention alsoprovides double-stranded RNA molecules that are modified to be resistant tonuclease degradation, which inactivates a virus, and more specifically,hepatitis C virus (HCV). The invention also provides a method of using thesemodified RNA molecules to inactivate virus in mammalian cells and method ofmaking modified small interfering RNAs (siRNAs) using human Dicer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/