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1-ОМЕГА-АРИЛОКСИАЛКИЛ- И 1-БЕНЗИЛЗАМЕЩЕННЫЕ 2-ИМИНОБЕНЗИМИДАЗОЛИНЫ И ИХ ФАРМАКОЛОГИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ОБЛАДАЮЩИЕ ПРОТИСТОЦИДНОЙ И АНТИМИКРОБНОЙ АКТИВНОСТЬЮ
专利权人:
GOSUDARSTVENNOE NAUCHNOE UCHREZHDENIE SEVERO-KAVKAZSKIJ ZONALNYJ NAUCHNO-ISSLEDOVATELSKIJ VETERINARNYJ INSTITUT (GNU SKZNIVI) ROSSIJSKOJ AKADEMII SELSKOKHOZJAJSTVENNYKH NAUK
发明人:
DIVAEVA LJUDMILA NIKOLAEVNA,Диваева Людмила Николаевна,MORKOVNIK ANATOLIJ SAVELEVICH,Морковник Анатолий Савельевич,KLIMENKO ALEKSANDR IVANOVICH,Клименко Александр Иванович,ZUBENKO ALEKSANDR ALEKSANDRO
申请号:
RU2012141810/04
公开号:
RU0002514196C1
申请日:
2012.10.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: present invention relates to novel 1-ω-aryloxyalkyl- and benzyl-substituted 2-iminobenzimidazolines and pharmacologically acceptable salts thereof of general formula 1 , where R = CH=CH2, R1 = 2-ClC6H4OCH2 (1b) R = CH=CH2, R1 = 4-ClC6H4OCH2 (1c) R = CH=CH2, R1 = 4-BrC6H4OCH2 (1d) R = CH=CH2, R1 = 2,4-Cl2C6H3OCH2 (1e) R = CH=CH2, R1 = 3,4-Cl2C6H3 (1f) R = CH=CH2, R1 = 4-FC6H4OCH2CH2 (1g) R = CH2N(C2H5)2, R1 = 4-C(CH3)3C6H4OCH2 (1h) R = CH2N(C2H5)2, R1 = 3,4-Cl2C6H3 (1i) R = R1 = 4-OCH3C6H4OCH2 (1j) R = 4-BrC6H4, R1 = 4-OCH3C6H4OCH2 (1k) R = 4-BrC6H4, R1 =2-OCH3C6H4OCH2 (1l) R = 4-NO2C6H4, R1 = 4-OCH3C6H4OCH2 (1m) R = 3,4-Cl2C6H3, R1 = 2-OCH3C6H4OCH2 (1n) R = 3,4-Cl2C6H3, R1 = 4-OCH3C6H4OCH2 (1o) R = C6H5OCH2, R1 = 4-OCH3C6H4OCH2 (1p) R = 2-CH3C6H4OCH2, R1 = 2-OCH3C6H4OCH2 (1q) R = 4-CH3C6H4OCH2, R1 = 2-OCH3C6H4OCH2 (1r) R = 4-C(CH3)3C6H4OCH2, R1 = 2-OCH3C6H4OCH2 (1s) R = 2-OCH3C6H4OCH2, R1 = 4-BrC6H4OCH2 (1t), having anti-protist and antibacterial activity.EFFECT: obtaining novel compounds with useful biological activity.1 tblНастоящее изобретение относится к новым 1-ω-арилоксиалкил- и бензилзамещенным 2-иминобензимидазолинам и их фармакологически приемлемым солям общей формулы 1, где R = СН=СН2, R1 = 2-ClC6H4OCH2 (1б) R = СН=СН2, R1 = 4-ClC6H4OCH2 (1в) R = СН=СН2, R1 = 4-BrC6H4OCH2 (1г) R = СН=СН2, R1 = 2,4-Cl2C6H3OCH2 (1д) R = СН=СН2, R1 = 3,4-Cl2C6H3 (1e) R = СН=СН2, R1 = 4-FC6H4OCH2CH2 (1ж) R = CH2N(C2H5)2, R1 = 4-C(CH3)3С6Н4ОСН2 (1з) R = CH2N(C2H5)2, R1 = 3,4-Cl2C6H3 (1к) R = R1 = 4-ОСН3С6Н4ОСН2 (1л) R = 4-BrC6H4, R1 = 4-ОСН3С6Н4ОСН2 (1м) R = 4-BrC6H4, R1 =2-ОСН3С6Н4ОСН2 (1н) R = 4-NO2C6H4, R1 = 4-ОСН3С6Н4ОСН2 (1o) R = 3,4-Cl2C6H3, R1 = 2-ОСН3С6Н4ОСН2 (1п) R = 3,4-Cl2C6H3, R1 = 4-ОСН3С6Н4ОСН2 (1p) R = С6Н5ОСН2, R1 = 4-ОСН3С6Н4ОСН2 (1c) R = 2-СН3С6Н4ОСН2, R1 = 2-ОСН3С6Н4ОСН2 (1т) R = 4-СН3С6Н4ОСН2, R1 = 2-OCH3C6H4OCH2 (1у) R = 4-С(СН3)3C6H4OCH2, R1 = 2-OCH3C6H4OCH2 (1ф) R = 2-OCH3C6H4OCH2, R1 = 4-BrC6H4OCH2 (1х), обладающим протистоцид
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