Kayvan Niazi,Gard Nelson,Wendy Higashide,Philip Liu
申请号：
US16440790
公开号：
US20200024326A1
申请日:
2019.06.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Self-activating chimeric signaling proteins, and especially chimeric TNF family member ligand-receptor proteins are contemplated. In preferred methods, the chimeric protein comprises an extracellular portion of CD40L that is coupled via a flexible linker to CD40 such that the fusion protein, when expressed in an APC, is capable of folding back on itself and transmits a CD40-mediated signal as if it had been contacted by CD40L located on another cell. Advantageously, cells expressing such chimeric proteins contemporaneously with presentation of an antigen will enhance an immune reaction against the antigen.
