Bone bypass shunts and methods using thereof. Method for affecting a pathophysiological condition in a body of a live subject includes exemplary steps/procedures of: connecting an inlet port of a bone bypass shunt to a first bone portion adjacent a first bone marrow location such that inlet port lumen of inlet port facilitates fluid communication with blood accumulated or flowing at first blood marrow location connecting outlet port of the bone bypass shunt to second bone portion adjacent second bone marrow location, such that outlet port lumen of outlet port facilitates fluid communication with bone marrow a formed cavity, or/and bone marrow vasculature, located at second bone marrow location via inlet port lumen, removing a chosen volume of blood from first bone marrow location and via outlet port lumen, delivering chosen volume of blood to the second bone marrow location.
