IMIDAZOQUINOLINE AND TETRAHYDROIMIDAZOQUINOLINE COMPOUNDS THAT CONTAIN SULFONAMIDE FUNCTIONALITY AT THE 1-POSITION ARE USEFUL AS IMMUNE RESPONSE MODIFIERS. THE COMPOUNDS AND COMPOSITIONS OF THE INVENTION CAN INDUCE THE BIOSYNTHESIS OF VARIOUS CYTOKINES AND ARE USEFUL IN THE TREATMENT OF A VARIETY OF CONDITIONS INCLUDING VIRAL DISEASES AND NEOPLASTIC DISEASES.