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PEPTIDE CYCLIQUE, SUPPORT DE CHROMATOGRAPHIE D'AFFINITE, ANTICORPS MARQUE, CONJUGUE ANTICORPS-MEDICAMENT ET PREPARATION PHARMACEUTIQUE
专利权人:
FUJIFILM CORPORATION
发明人:
MINAMI, KOICHI
申请号:
CA3000979
公开号:
CA3000979A1
申请日:
2016.10.21
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Provided is a cyclic peptide that is represented by formula (I) or formula (I'), has excellent antibody-binding characteristics, and also has improved drug stability. Also provided are an affinity chromatography support, a labeled antibody, an antibody-drug conjugate, and a pharmaceutical preparation. RN-Xg-[Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj]k-Xh-RC...(I) In formula (I): Xa and Xb each independently represents an amino acid residue derived from an amino acid that has a thiol group in a side chain thereof other than L-cysteine and D-cysteine, Xa and Xb each being bonded via a disulfide bond; or one of Xa and Xb represents an amino acid residue derived from an amino acid that has a thiol group in a side chain thereof other than L-cysteine and D-cysteine and the other represents an amino acid residue derived from an amino acid that has a haloacetyl group in a side chain thereof, Xa and Xb each being bonded via a thioether bond. RN-Xg-[Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj]k-Xh-RC...(I') In formula (I'): one of Xa and Xb represents an amino acid residue derived from L-cysteine or D-cysteine and the other represents an amino acid residue derived from an amino acid that has a haloacetyl group in a side chain thereof, Xa and Xb each being bonded via a thioether bond; or one of Xa and Xb represents an amino acid residue derived from L-penicillamine or D-penicillamine and the other represents an amino acid residue derived from an amino acid that has a haloacetyl group in a side chain thereof, Xa and Xb each being bonded via a thioether bond.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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