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PEPTIDE CYCLIQUE, SUPPORT DE CHROMATOGRAPHIE D'AFFINITÉ, ANTICORPS MARQUÉ, CONJUGUÉ ANTICORPS-MÉDICAMENT ET PRÉPARATION PHARMACEUTIQUE
专利权人:
FUJIFILM Corporation
发明人:
申请号:
EP16857582.7
公开号:
EP3366693A1
申请日:
2016.10.21
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Provided is a cyclic peptide, which is represented by Formula (I) or Formula (I') and has excellent antibody binding properties and improved chemical resistance, an affinity chromatography support, a labeled antibody, an antibody drug conjugate, and a pharmaceutical preparation.        RN-Xg-[Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj]k-Xh-RC ···     (I)In Formula (I), Xa and Xb each independently represent an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain and are bonded to each other through a disulfide bond, or, one of Xa and Xb represents an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and Xa and Xb are bonded to each other through a thioether bond.        RN-Xg-[Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj]k-Xh-RC ···     (I')In Formula (I'), one of Xa and Xb represents an amino acid residue derived from L-cysteine or D-cysteine and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and Xa and Xb are bonded to each other through a thioether bond, or, one of Xa and Xb represents an amino acid residue derived from L-penicillamine or D-penicillamine and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and Xa and Xb are bonded to each other through a thioether bond.
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