Robert G. Aslanian;Michael Sofolarides;Sylvia Degrado;Wei Zhou;Anandan Palani;Xiao Chen;Dong Xiao;Xianhai Huang
发明人:
Dong Xiao,Anandan Palani,Robert G. Aslanian,Sylvia Degrado,Xianhai Huang,Wei Zhou,Michael Sofolarides,Xiao Chen
申请号:
US13515638
公开号:
US08598158B2
申请日:
2010.12.09
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to certain lactam ring-containing compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein D, E, X1, R1, R2, R3, R4, R9, and R10 are as herein described. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, and chronic obstructive pulmonary disorder.