Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a biological activity factor and a biodegradable copolymer. The biodegradable copolymer has a structure of formula (I) or formula (II)wherein、A comprises a hydrophilic polyethylene glycol polymer； B comprises a hydrophobic polyester polymer； BOX is bifunctional group monomer of 2、2'-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B； and n is an integer and the same or more than 0.本發明提供一種治療骨疾病之溫度敏感性組合物，包含：一生物活性因子；以及一生物可分解共聚合物，其中該共聚合物具有A嵌段高分子和B嵌段高分子，且符合下列公式(I)或(II)所示結構：其中，A嵌段高分子係為一親水性聚乙二醇聚合物(hydrophilic polyethylene glycol polymer)；B嵌段高分子係為一疏水性聚酯聚合物(hydrophobic polyester polymer)；以及BOX係為2、2'-雙(2-噁唑啉)(2、2'-Bis(2-oxazoline))之雙官能基單體，用以交聯兩團聯A-B或三團聯B-A-B；以及n係為一整數，且n0。
