METHODS AND COMPOSITIONS COMPRISING VIRAL GENE THERAPY AND AN IMMUNE CHECKPOINT INHIBITOR FOR TREATMENT AND PREVENTION OF CANCER AND INFECTIOUS DISEASES
Robert E. SOBOL,Kerstin B. MENANDER,Dora WIEDERHOLD,Sunil CHADA
申请号：
US16468408
公开号：
US20200009203A1
申请日:
2017.12.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a viral composition comprising one or more viruses engineered to comprise an N1L gene deletion, a matrix-degrading protein gene, an adenoviral death protein (ADP) gene, and/or a cytochrome p450 gene. Also provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of a viral composition comprising two or more viruses engineered to comprise an N1L gene deletion a matrix-degrading protein gene, an adenoviral death protein (ADP) gene, and/or a cytochrome p450 gene. Also provided herein are methods of enhancing antitumor efficacy by administering the agents described above in combination with other cancer therapies.
