Provided herein are chemical matrices, compositions, and methods for the treatment of skin diseases and disorders in an individual. Said chemical matrices and compositions comprise an alcohol selected from ethanol, isopropanol or n-propanol, at least one excipient, and, a corticosteroid, wherein the alcohol is distributed within the chemical matrix as a microbubble and the corticosteroid is present in less than the standardized topical corticosteroid concentration. Additionally, methods are described for the use of said chemical matrices and compositions for the treatment of skin diseases and disorders.
