RNA containing modified nucleosides and methods of use thereof

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专利权人:

发明人:

Katalin Kariko,Drew Weissman

申请号：

US13839023

公开号：

US08835108B2

申请日:

2013.03.15

申请国别(地区):

US

年份:

2014

代理人:

摘要：

This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/