Módosított nukleozidokat tartalmazó RNS és eljárások az alkalmazására

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专利权人:

The Trustees of The University of Pennsylvania

发明人:

Kariko, Katalin,Weissman, Drew

申请号：

HUE12008048

公开号：

HUE043492T2

申请日:

2006.08.21

申请国别(地区):

HU

年份:

2019

代理人:

摘要：

This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/