METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR

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专利权人:

发明人:

申请号：

EP11800027.2

公开号：

EP2588110A1

申请日:

2011.07.04

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.

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