David D. Newbold;Dwayne T. Friesen;Devon B. Dubose;Douglas L. Millard;John M. Baumann
发明人:
Dwayne T. Friesen,David D. Newbold,John M. Baumann,Devon B. Dubose,Douglas L. Millard
申请号：
US13259082
公开号：
US20120015924A1
申请日:
2010.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
