Cosmetic use of a urea compound (I) in a composition (A) comprising a medium, as an agent for stimulating the exfoliation of skin and/or mucous membranes. Cosmetic use of a urea compound (I) of formula (R1R2N-CO-NR3R4) in a composition (A) comprising a medium, as an agent for stimulating the exfoliation of skin and/or mucous membranes. R1-R4 : H, 1-4C alkyl or 2-6C hydroxy alkyl (containing 1-5 OH). Provided that at least one of R1-R4 is hydroxyalkyl. Independent claims are included for: (1) a process of cosmetic treatment of the keratinous tissues, comprising applying a first component containing (I) and a second component containing an agent e.g. protease, lipase and glycosidase, where the two components are applied simultaneously, together or sequentially to the skin, mucous membranes or superficial body growths； (2) a cosmetic agent in the form of kit comprising the first component containing (I) and the second component containing e.g. protease, lipase and glycosidase； (3) a cosmetic unit comprising a container delimited with a compartment, where the container is closed by a closing element and the composition is disposed inside the compartment； and (4) a process of selection of exfoliating compounds comprising (a) preparing a stratum corneum extract containing acid proteases； (b) mixing a marked proteinic substrate with the compound to be tested at different concentrations, and with a proteolytic urea at one concentration, to obtain mixtures comprising the compound to be tested or the urea； (c) contacting the obtained extract fractions from (a) with the various obtained mixtures from (b) to obtain reaction mixtures comprising the compound to be tested or the urea, or with a marked casein substrate to obtain a control； and (d) after a time of incubation, comparing proteolysis reaction in the various reaction mixtures and selecting the compound in which the intensity of proteolysis is higher than the one of the control. ACTIVITY : Antipsoriatic； Dermatological；
