Cosmetic use of C-glycoside derivative (I) in a composition comprising a medium, as cosmetics to promote the desquamation of skin and/or scalp and/or to stimulate epidermal renewal. Independent claims are included for: (1) a cosmetic treatment to promote desquamation and/or stimulate the epidermal renewal, to promote the complexion brilliance and/or reduce the surface irregularities of the skin and/or mucous membranes, comprising application of a composition comprising (I) in a medium, on the skin and/or the scalp; and (2) a cosmetic treatment of keratinous materials comprising application of a first component comprising (I) and a second component comprising proteases, lipases and glycosidases, simultaneously, together or sequentially on the skin, mucous membranes or the scalp.